Congenital Adrenal Hyperplasia Insights

In the treatment of congenital adrenal hyperplasia (CAH), Neumann et al. (2025) discuss the use of modified release hydrocortisone in adolescents. Traditional immediate release hydrocortisone doesn't align well with the body's natural cortisol patterns, often requiring doses that are higher than what's naturally occurring, and must be taken multiple times a day. This can make it hard to get the dosage right and can lead to unwanted side effects.

The experts suggest using Hydrocortisone Modified Release Capsules, which have been shown to be effective in adults and are now approved for use in adolescents 12 years and older. This new formulation releases the medication in a way that better mimics the body's own rhythms, potentially improving treatment outcomes. The article outlines dosing strategies, monitoring protocols, and emphasizes the importance of gathering more data on the effectiveness of this treatment in younger patients.