Congenital Adrenal Hyperplasia Insights

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In a study by Krishnan et al. (2025), researchers examined the long-term outcomes of feminizing genitoplasty in patients with congenital adrenal hyperplasia (CAH). The retrospective study included 43 patients who had undergone the procedure, most before the age of one. Findings revealed that 63% of these patients did not require further surgeries after the initial reconstruction. However, among the post-menarchal patients, there were instances of vaginal stenosis and menstrual obstruction, leading to additional surgeries. The study also found that screening examination under anesthesia (sEUA) for asymptomatic patients might be unnecessary, as it rarely led to further surgery recommendations. The research highlighted the importance of continued observation and uniform gynecologic care to better understand the outcomes of feminizing genitoplasty in CAH patients.

Despite the majority not needing additional surgeries, some patients did experience complications such as vaginal stenosis, menstrual obstruction, and dyspareunia (painful sexual intercourse). The study by Krishnan et al. suggests that sEUA could be reserved for symptomatic patients due to the low rate of abnormal findings in asymptomatic individuals. The research underscores the need for more comprehensive follow-up and documentation to improve care for CAH patients after genitoplasty.